GPCRdb

ABT-239

Agent/drug
Bioactivity

ABT-239

SMILES	C[C@@H]1CCCN1CCc1cc2cc(-c3ccc(C#N)cc3)ccc2o1
InChIKey	KFHYZKCRXNRKRC-MRXNPFEDSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	330.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₁	HRH1	Human	Histamine	A	pKi	5.80	5.80	5.80	Guide to Pharmacology
H₂	HRH2	Human	Histamine	A	pKi	5.20	5.20	5.20	Guide to Pharmacology
H₃	HRH3	Human	Histamine	A	pKi	9.40	9.40	9.40	Guide to Pharmacology
H₃	HRH3	Rat	Histamine	A	pKi	8.90	8.90	8.90	Guide to Pharmacology
H₃	HRH3	Rat	Histamine	A	pKi	7.51	8.63	9.35	ChEMBL
H₃	HRH3	Human	Histamine	A	pKi	8.04	9.10	9.40	ChEMBL
H₃	HRH3	Human	Histamine	A	pKd	7.89	7.89	7.89	ChEMBL

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₃	HRH3	Rat	Histamine	A	pEC50	7.76	7.76	7.76	ChEMBL
H₃	HRH3	Human	Histamine	A	pIC50	9.20	9.20	9.20	ChEMBL
H₃	HRH3	Human	Histamine	A	pEC50	8.89	8.89	8.89	ChEMBL

Showing 1 to 3 of 3 entries

ABT-239

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.