GPCRdb

loratadine

Agent/drug
Bioactivity

loratadine

SMILES	CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1
InChIKey	JCCNYMKQOSZNPW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	1
Molecular weight (Da)	382.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	H₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.81	6.81	6.81	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	7.43	7.43	7.43	Guide to Pharmacology
H₁	HRH1	Rat	Histamine	A	pKi	6.46	6.46	6.46	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKd	7.14	7.14	7.14	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	6.38	7.00	7.70	ChEMBL
H₁	HRH1	Human	Histamine	A	pKd	6.72	6.72	6.72	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKd	8.15	8.15	8.15	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	8.16	8.16	8.16	Drug Central
H₁	HRH1	Rat	Histamine	A	pKi	8.19	8.19	8.19	Drug Central

Showing 1 to 10 of 10 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.61	6.61	6.61	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	6.54	6.65	6.77	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.70	5.30	5.90	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	5.13	5.40	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.40	4.55	4.70	ChEMBL

Showing 1 to 5 of 5 entries

loratadine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 1

Phase II 5

Phase III 1

Phase IV 6

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	H₁

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Allergic or hypersensitivity conditions of unspecified type	4	4A8Z	R06A	0.494
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Allergic rhinitis due to other seasonal allergens	4	CA08.01	R06A	0.610
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Allergic rhinitis, unspecified	4	CA08.0Z	R06A	0.616
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Asthma	3	CA23	R06A	0.545
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Atopic eczema, unspecified	1	EA80.Z	R06A	0.474
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	COVID-19	2	RA01	R06A	0.486
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Eosinophilic oesophagitis	2	DA24.1	R06A	0.082
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Lymphangioleiomyomatosis, unspecified	2	CB07.Z	R06A	0.076
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Other allergic rhinitis	4	CA08.03	R06A	0.602
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Pain, unspecified	2	MG3Z	R06A	0.591
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Pruritus, unspecified	4	EC90.Z	R06A	0.602
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Spinal pain, unspecified	2	ME84.Z	R06A	0.470
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Urticaria of unspecified type	4	EB05	R06A	0.606

Showing 1 to 13 of 13 entries