GPCRdb

SORAFENIB

Agent/drug
Bioactivity

SORAFENIB

SMILES	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1
InChIKey	MLDQJTXFUGDVEO-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	3
Rotatable bonds	5
Molecular weight (Da)	464.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.93	5.93	5.93	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.71	5.71	5.71	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.25	7.25	7.25	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.38	6.38	6.38	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Drug Central
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	5.48	5.48	5.48	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	8.26	8.26	8.26	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.21	5.21	5.21	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.28	8.28	8.28	Drug Central
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.15	5.15	5.15	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.29	8.29	8.29	Drug Central

Showing 1 to 14 of 14 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

MC₄	MC4R	Human	Melanocortin	A	pIC50	5.35	5.35	5.35	ChEMBL
NTS₁	NTR1	Human	Neurotensin	A	pEC50	4.84	4.84	4.84	ChEMBL

Showing 1 to 2 of 2 entries

SORAFENIB

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.