GPCRdb

metergoline

Agent/drug
Bioactivity

metergoline

SMILES	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21
InChIKey	WZHJKEUHNJHDLS-QTGUNEKASA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	403.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank GPCRdb
Ligand site mutations	5-HT_1A 5-HT_1B 5-HT_1D 5-HT_2C 5-HT₆

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.42	7.42	7.42	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.84	6.84	6.84	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.17	7.17	7.17	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.66	7.66	7.66	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.57	7.57	7.57	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.22	8.34	8.45	ChEMBL
5-HT_1A	A0A4X1UTF5	Pig	5-Hydroxytryptamine	A	pKi	8.10	8.14	8.26	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.89	8.27	8.64	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.56	7.60	8.46	PDSP Ki database
5-HT_1A	F6Q2H9	Bovine	5-Hydroxytryptamine	A	pKi	7.15	7.15	7.15	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.06	8.06	8.06	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.36	8.36	8.36	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	7.20	7.20	7.20	Guide to Pharmacology

Showing 1 to 20 of 92 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.02	7.02	7.02	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.15	8.15	8.15	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.58	6.58	6.58	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.87	6.87	6.87	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	7.24	7.24	7.24	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.80	7.80	7.80	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.72	6.72	6.72	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.21	8.21	8.21	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	8.12	8.12	8.12	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	8.39	8.39	8.39	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	7.72	7.72	7.72	ChEMBL
5-HT_1F	5HT1F	Rat	5-Hydroxytryptamine	A	pIC50	6.30	6.30	6.30	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	9.40	9.40	9.40	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	9.36	9.36	9.36	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	9.18	9.18	9.18	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.55	7.55	7.55	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	7.13	7.13	7.13	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	7.20	7.20	7.20	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	8.11	8.11	8.11	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	5.38	5.38	5.38	ChEMBL

Showing 1 to 20 of 23 entries

metergoline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank GPCRdb
Ligand site mutations	5-HT_1A 5-HT_1B 5-HT_1D 5-HT_2C 5-HT₆

Compound is not listed as a drug.