MK-2894


SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C
InChIKey QJZQFVRFJCGDKF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 473.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Human Prostanoid A pKi 9.25 9.25 9.25 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pKi 5.48 5.48 5.48 ChEMBL
EP2 PE2R2 Rat Prostanoid A pKi 5.14 5.14 5.14 ChEMBL
EP4 PE2R4 Human Prostanoid A pKi 9.01 9.19 9.3 ChEMBL
EP2 PE2R2 Human Prostanoid A pKi 5.23 5.23 5.23 ChEMBL
EP4 PE2R4 Rat Prostanoid A pKi 9.15 9.15 9.15 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Human Prostanoid A pIC50 7.96 8.42 8.6 ChEMBL