GPCRdb

mitragynine

Agent/drug
Bioactivity

mitragynine

SMILES	CC[C@@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
InChIKey	LELBFTMXCIIKKX-QVRQZEMUSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	398.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	5.87	5.87	5.87	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.32	5.32	5.32	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.26	5.26	5.26	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.33	5.33	5.33	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.03	5.03	5.03	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.63	5.63	5.63	ChEMBL
δ	OPRD	Mouse	Opioid	A	pKi	6.00	6.00	6.00	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	7.22	7.22	7.22	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	6.11	6.41	6.70	ChEMBL
κ	OPRK	Mouse	Opioid	A	pKi	6.64	6.64	6.64	ChEMBL
κ	OPRK	Guinea pig	Opioid	A	pKi	5.96	6.44	6.91	ChEMBL
μ	OPRM	Mouse	Opioid	A	pKi	6.64	6.64	6.64	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	6.63	6.74	6.79	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.23	5.23	5.23	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.30	5.30	5.30	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.90	5.90	5.90	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	ChEMBL

Showing 1 to 17 of 17 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

κ	OPRK	Human	Opioid	A	pEC50	5.07	5.07	5.07	ChEMBL
κ	OPRK	Guinea pig	Opioid	A	pEC50	6.64	6.64	6.64	ChEMBL
μ	OPRM	Mouse	Opioid	A	pEC50	6.69	6.69	6.69	Guide to Pharmacology
μ	OPRM	Mouse	Opioid	A	pEC50	6.69	6.69	6.69	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	6.47	7.08	9.31	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	9.30	9.30	9.30	Guide to Pharmacology

Showing 1 to 6 of 6 entries

mitragynine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.