GPCRdb

nemonapride

Agent/drug
Bioactivity

nemonapride

SMILES	CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)C2C)cc1Cl
InChIKey	KRVOJOCLBAAKSJ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	387.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	D₂ D₃

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.82	8.03	8.24	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.55	5.55	5.55	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.53	6.53	6.53	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.25	7.25	7.25	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.32	6.32	6.32	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.51	5.51	5.51	PDSP Ki database
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	5.81	5.81	5.81	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.34	7.34	7.34	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	7.09	7.09	7.09	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.58	5.58	5.58	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	9.80	9.80	9.80	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKd	10.80	10.82	10.85	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.58	8.58	8.58	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	10.00	10.31	11.00	PDSP Ki database
D₂	A0A287B0Q7	Pig	Dopamine	A	pKi	9.85	10.18	10.40	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	10.52	10.61	10.70	PDSP Ki database
D₂	DRD2	Dog	Dopamine	A	pKi	10.22	10.22	10.22	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	9.20	9.25	9.30	Guide to Pharmacology
D₃	DRD3	Rat	Dopamine	A	pKi	9.80	9.80	9.80	ChEMBL

Showing 1 to 20 of 28 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.27	6.27	6.27	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	9.32	9.32	9.32	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	7.01	7.01	7.01	ChEMBL

Showing 1 to 3 of 3 entries

nemonapride

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	D₂ D₃

Compound is not listed as a drug.