GPCRdb

olanzapine

Agent/drug
Bioactivity

olanzapine

SMILES	Cc1cc2c(s1)=Nc1ccccc1NC=2N1CCN(C)CC1
InChIKey	WXPNDRBBWZMPQG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	1
Molecular weight (Da)	312.1

Database connections

PubChem Guide To Pharmacology DrugBank ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	5-HT_1A 5-HT_2C 5-HT₇ D₂ D₄

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.58	7.59	7.60	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.00	6.81	7.22	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.16	7.42	7.68	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.00	6.00	6.00	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.58	6.58	6.58	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.35	7.35	7.35	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.94	7.04	7.22	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.00	6.47	6.72	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.33	6.51	6.72	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.72	6.86	7.00	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.74	6.97	7.09	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.00	7.07	7.11	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.68	7.21	7.54	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central

Showing 1 to 20 of 155 entries

…

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.19	7.19	7.19	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.14	8.14	8.14	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pA2	7.40	7.40	7.40	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	7.43	7.43	7.43	ChEMBL
α_1D	ADA1D	Rat	Adrenoceptors	A	pA2	6.40	6.40	6.40	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.04	7.04	7.04	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.27	6.27	6.27	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.38	6.38	6.38	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.28	6.28	6.28	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	6.15	6.15	6.15	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.00	7.88	8.30	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.24	7.24	7.24	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.15	7.42	7.68	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.89	7.89	7.89	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	7.14	7.14	7.14	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	6.80	6.80	6.80	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.93	7.46	8.00	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.11	7.11	7.11	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	6.76	6.76	6.76	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	7.89	7.89	7.89	ChEMBL

Showing 1 to 20 of 24 entries

olanzapine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 10

Phase II 28

Phase III 51

Phase IV 37

Database connections

PubChem Guide To Pharmacology DrugBank ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	5-HT_1A 5-HT_2C 5-HT₇ D₂ D₄

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Alcohol dependence, unspecified	3	6C40.2Z	N05A	0.268
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Anorexia	3	MG43.7	N05A	0.293
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Anorexia Nervosa, unspecified	3	6B80.Z	N05A	0.508
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	2	6A02.Z	N05A	0.462
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	4	6A60.Z	N05A	0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Delirium, unspecified or unknown cause	2	6D70.Z	N05A	0.588
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	4	6A7Z	N05A	0.607
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Disorders due to use of opioids, unspecified	2	6C43.Z	N05A	0.108
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Disorders of intellectual development, unspecified	3	6A00.Z	N05A	0.360
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Excessive weight loss	2	MG43.5	N05A	0.083
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Gambling disorder, unspecified	3	6C50.Z	N05A	0.259
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Huntington disease	3	8A01.10	N05A	0.275
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Hypoalphalipoproteinaemia	1	5C81.0	N05A	0.054
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Mood disorders, unspecified	1	6A8Z	N05A	0.490
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Nausea	3	MD90.0	N05A	0.337
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Nausea or vomiting	3	MD90	N05A	0.543
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Other specified depressive disorders	3	6A7Y	N05A	0.552
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Personality disorder, severity unspecified	3	6D10.Z	N05A	0.507
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Restlessness	4	MB24.F	N05A	0.602
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Schizoaffective disorder, unspecified	4	6A21.Z	N05A	0.606

Showing 1 to 20 of 120 entries

Join us

Cite us

Main reference

olanzapine

olanzapine

Chemical Properties

Database connections

Bioactivities

olanzapine

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information