GPCRdb

OXATOMIDE

Agent/drug
Bioactivity

OXATOMIDE

SMILES	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1
InChIKey	BAINIUMDFURPJM-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	426.2

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	7.20	7.20	7.20	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.14	8.14	8.14	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	8.11	8.11	8.11	Drug Central
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.21	8.21	8.21	Drug Central

Showing 1 to 6 of 6 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₁	HRH1	Guinea pig	Histamine	A	pIC50	8.05	8.05	8.05	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pIC50	8.09	8.09	8.09	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.80	5.05	5.30	ChEMBL

Showing 1 to 3 of 3 entries

OXATOMIDE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 1

Phase III 0

Approved Yes

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z		0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Duchenne muscular dystrophy	8C70.1		0.074	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05		0.606	4	Yes

Showing 1 to 3 of 3 entries