phenoxybenzamine


SMILES ClCCN(C(COc1ccccc1)C)Cc1ccccc1
InChIKey QZVCTJOXCFMACW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 8
Molecular weight (Da) 303.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α2A

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pKi 8.46 8.46 8.46 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 6.85 6.85 6.85 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.5 8.5 8.5 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TSH TSHR Human Glycoprotein hormone A Potency 7.2 7.2 7.2 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 8.14 8.14 8.14 Drug Central
α2A ADA2A Human Adrenoceptors A pIC50 8.2 8.2 8.2 Drug Central
NPS NPSR1 Human Neuropeptide S A Potency 4.6 4.85 5.1 ChEMBL