GPCRdb

PF-04995274

Agent/drug
Bioactivity

PF-04995274

SMILES	OC1(CN2CCC(COc3noc4cccc(O[C@@H]5CCOC5)c34)CC2)CCOCC1
InChIKey	WLLOFQROROXOMO-GOSISDBHSA-N

Chemical Properties

Hydrogen bond acceptors	8
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	432.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	9.82	9.82	9.82	Guide to Pharmacology
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pKi	9.52	9.52	9.52	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	9.34	9.52	9.82	ChEMBL

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pEC50	9.19	9.21	9.23	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pEC50	8.82	9.28	9.70	ChEMBL

Showing 1 to 2 of 2 entries

PF-04995274

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb

Compound is not listed as a drug.