GPCRdb

O-DESMETHYL TRAMADOL

Agent/drug
Bioactivity

O-DESMETHYL TRAMADOL

SMILES	CN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1
InChIKey	UWJUQVWARXYRCG-HIFRSBDPSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	3
Molecular weight (Da)	249.2

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Human	Opioid	A	pKi	5.54	5.54	5.54	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	6.35	6.35	6.35	ChEMBL
μ	OPRM	Mouse	Opioid	A	pKi	7.89	7.89	7.89	ChEMBL
μ	OPRM	Rat	Opioid	A	pKi	7.89	7.89	7.89	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	7.89	7.97	8.07	ChEMBL

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

μ	OPRM	Rat	Opioid	A	pEC50	6.61	6.61	6.61	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	7.33	7.34	7.37	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	6.61	6.72	6.92	ChEMBL

Showing 1 to 3 of 3 entries

O-DESMETHYL TRAMADOL

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.