GPCRdb

quipazine

Agent/drug
Bioactivity

quipazine

SMILES	c1ccc2nc(N3CCNCC3)ccc2c1
InChIKey	XRXDAJYKGWNHTQ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	1
Molecular weight (Da)	213.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT_2C

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pKd	5.25	5.25	5.25	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.20	5.20	5.20	ChEMBL
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.54	5.54	5.54	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.44	5.65	5.82	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	5.70	5.70	5.70	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.64	6.64	6.64	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.38	5.77	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.47	5.70	5.93	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.50	6.58	6.70	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.51	6.58	6.72	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.69	5.87	6.10	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.43	5.80	6.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.56	6.53	7.23	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.10	7.10	7.10	Guide to Pharmacology
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
5-HT_2B	F6QI78	Bovine	5-Hydroxytryptamine	A	pKi	6.34	6.34	6.34	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.75	7.04	7.31	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	5.20	6.32	6.89	PDSP Ki database

Showing 1 to 20 of 35 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.57	5.57	5.57	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	5.84	5.84	5.84	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.15	5.57	6.42	ChEMBL
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pIC50	5.46	5.46	5.46	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	6.33	6.33	6.33	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.21	7.21	7.21	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.60	4.92	5.25	ChEMBL

Showing 1 to 7 of 7 entries

quipazine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT_2C

Compound is not listed as a drug.