RF9


SMILES NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3
InChIKey UMKHUSRDQFQHAK-RNJMTYCLSA-N
Sequence None

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NPFF1 NPFF1 Human Neuropeptide FF/neuropeptide AF A pKi 7.24 7.58 7.85 ChEMBL
NPFF2 NPFF2 Human Neuropeptide FF/neuropeptide AF A pKi 7.12 7.41 7.75 ChEMBL
NPFF1 NPFF1 Human Neuropeptide FF/neuropeptide AF A pKi 7.2 7.2 7.2 Guide to Pharmacology
NPFF2 NPFF2 Human Neuropeptide FF/neuropeptide AF A pKi 7.1 7.1 7.1 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MRGPRX1 MRGX1 Mouse A orphans A pEC50 6.5 6.5 6.5 ChEMBL
MRGPRX1 MRGX1 Rat A orphans A pEC50 5.2 5.2 5.2 ChEMBL
NPFF1 NPFF1 Human Neuropeptide FF/neuropeptide AF A pEC50 5.33 6.27 7.15 ChEMBL
NPFF1 NPFF1 Human Neuropeptide FF/neuropeptide AF A pIC50 6.39 6.39 6.39 ChEMBL
NPFF2 NPFF2 Human Neuropeptide FF/neuropeptide AF A pEC50 6.33 6.38 6.42 ChEMBL
NPFF2 NPFF2 Human Neuropeptide FF/neuropeptide AF A pIC50 6.39 6.39 6.39 ChEMBL
kisspeptin KISSR Human Kisspeptin A pIC50 6.08 6.08 6.08 ChEMBL