GPCRdb

(R)-Ro65-6570

Agent/drug
Bioactivity

(R)-Ro65-6570

SMILES	O=C1NCN(c2ccccc2)C12CCN([C@@H]1Cc3cccc4cccc1c34)CC2
InChIKey	BBOAHBVXCYBKLC-JOCHJYFZSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	383.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Human	Opioid	A	pKi	7.00	7.00	7.00	ChEMBL
δ	OPRD	Rat	Opioid	A	pKi	7.00	7.00	7.00	ChEMBL
κ	OPRK	Rat	Opioid	A	pKi	7.70	7.70	7.70	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	7.70	7.70	7.70	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.40	8.40	8.40	ChEMBL
μ	OPRM	Rat	Opioid	A	pKi	8.40	8.40	8.40	ChEMBL
NOP	OPRX	Human	Opioid	A	pKi	9.60	9.60	9.60	Guide to Pharmacology
NOP	OPRX	Rat	Opioid	A	pKi	9.39	9.39	9.39	ChEMBL
NOP	OPRX	Human	Opioid	A	pKi	9.60	9.60	9.60	ChEMBL

Showing 1 to 9 of 9 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

NOP	OPRX	Human	Opioid	A	pEC50	7.40	7.40	7.40	Guide to Pharmacology
NOP	OPRX	Human	Opioid	A	pEC50	7.40	7.40	7.40	ChEMBL

Showing 1 to 2 of 2 entries

(R)-Ro65-6570

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.