GPCRdb

R-VK4-40

Agent/drug
Bioactivity

R-VK4-40

SMILES	CCc1cccc(N2CCN(C[C@H](O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl
InChIKey	OIRZLTZLOKARTG-HXUWFJFHSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	3
Rotatable bonds	8
Molecular weight (Da)	454.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.61	6.61	6.61	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.67	7.67	7.67	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.30	7.30	7.30	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.12	7.12	7.12	Guide to Pharmacology
D₂	DRD2	Human	Dopamine	A	pKi	7.12	7.12	7.12	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	9.54	9.54	9.54	Guide to Pharmacology
D₃	DRD3	Human	Dopamine	A	pKi	9.54	9.54	9.54	ChEMBL

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	5.98	5.98	5.98	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.73	7.73	7.73	ChEMBL

Showing 1 to 2 of 2 entries

R-VK4-40

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.