GPCRdb

SB 204741

Agent/drug
Bioactivity

SB 204741

SMILES	Cc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)sn1
InChIKey	USFUFHFQWXDVMH-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	286.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.10	5.30	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.95	7.95	7.95	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.90	7.10	7.29	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	7.30	7.55	7.80	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKd	7.95	7.95	7.95	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.60	5.60	5.60	Guide to Pharmacology
5-HT_2C	5HT2C	Mouse	5-Hydroxytryptamine	A	pKi	5.82	5.82	5.82	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.82	5.82	5.82	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.56	5.73	6.00	PDSP Ki database
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₁	HRH1	Guinea pig	Histamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 18 of 18 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.80	4.80	4.80	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	6.00	6.00	6.00	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.40	4.40	4.40	ChEMBL

Showing 1 to 3 of 3 entries

SB 204741

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.