GPCRdb

SB269970

Agent/drug
Bioactivity

SB269970

SMILES	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
InChIKey	HWKROQUZSKPIKQ-MRXNPFEDSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	352.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Guide To Pharmacology GPCRdb
Ligand site mutations	5-HT₇

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.93	5.93	5.93	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.51	6.51	6.51	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.76	5.76	5.76	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	6.35	6.35	6.35	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	6.73	6.73	6.73	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.04	5.04	5.04	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.77	5.88	6.00	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.80	5.80	5.80	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.00	6.65	8.30	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	5.90	5.90	5.90	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	7.19	7.72	9.11	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.20	5.20	5.20	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.60	8.75	8.90	Guide to Pharmacology
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKd	8.92	8.92	8.92	Guide to Pharmacology
5-HT₇	5HT7R	Guinea pig	5-Hydroxytryptamine	A	pKd	7.48	7.90	8.40	ChEMBL
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	7.50	8.47	9.00	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.72	9.09	9.47	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKd	8.01	8.01	8.01	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	6.50	6.50	6.50	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.60	5.92	6.25	ChEMBL

Showing 1 to 20 of 20 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pIC50	8.43	8.83	9.30	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL

Showing 1 to 2 of 2 entries

SB269970

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Guide To Pharmacology GPCRdb
Ligand site mutations	5-HT₇

Compound is not listed as a drug.