GPCRdb

SB 271046

Agent/drug
Bioactivity

SB 271046

SMILES	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1
InChIKey	LOCQRDBFWSXQQI-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	6
Hydrogen bond donors	2
Rotatable bonds	5
Molecular weight (Da)	451.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT₆

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.58	5.66	5.70	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.23	6.23	6.23	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.35	5.35	5.35	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.68	5.68	5.68	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	6.05	6.05	6.05	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	5.45	5.45	5.45	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.40	6.42	6.47	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.10	6.10	6.10	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.97	6.39	6.60	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.76	5.76	5.76	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.09	6.09	6.09	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.70	5.96	6.28	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pKi	5.40	5.40	5.40	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	5.72	5.72	5.72	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.90	8.90	8.90	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.89	8.86	9.20	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.40	6.47	8.52	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	6.92	6.92	6.92	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.60	5.85	6.34	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.88	6.25	6.50	ChEMBL

Showing 1 to 20 of 21 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	8.70	8.70	8.70	ChEMBL
CX₃CR1	CX3C1	Human	Chemokine	A	pIC50	5.42	5.42	5.42	ChEMBL
FPR3	FPR3	Human	Formylpeptide	A	pIC50	5.37	5.37	5.37	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.20	5.20	5.20	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.39	5.39	5.39	ChEMBL

Showing 1 to 5 of 5 entries

SB 271046

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT₆

Compound is not listed as a drug.