GPCRdb

SB-282241

Agent/drug
Bioactivity

SB-282241

SMILES	O=C(/C=C/c1ccc(Cl)c(Cl)c1)NCCCCCN1CCC(c2c[nH]c3ccc(O)cc23)CC1
InChIKey	QBRLVMQBZIFWTB-WEVVVXLNSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	3
Rotatable bonds	9
Molecular weight (Da)	499.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	CCR2

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.00	7.00	7.00	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	7.90	7.90	7.90	ChEMBL
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	ChEMBL
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	8.50	8.50	8.50	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.70	7.70	7.70	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.60	7.60	7.60	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.10	7.10	7.10	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.10	7.10	7.10	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	7.20	7.20	7.20	ChEMBL
CCR2	CCR2	Human	Chemokine	A	pKi	7.00	7.00	7.00	Guide to Pharmacology
CCR2	CCR2	Human	Chemokine	A	pKi	5.60	6.83	7.78	ChEMBL
CCR5	CCR5	Human	Chemokine	A	pKi	5.37	5.37	5.37	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.80	7.80	7.80	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.10	8.10	8.10	ChEMBL

Showing 1 to 14 of 14 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CCR2	CCR2	Human	Chemokine	A	pIC50	7.00	7.00	7.00	ChEMBL

Showing 1 to 1 of 1 entry

SB-282241

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	CCR2

Compound is not listed as a drug.