GPCRdb

SKF-83566

Agent/drug
Bioactivity

SKF-83566

SMILES	CN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1
InChIKey	XFTVOHWWEQGXLS-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	1
Molecular weight (Da)	331.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	5.83	5.83	5.83	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.54	5.54	5.54	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.66	5.66	5.66	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.10	6.10	6.10	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.55	5.55	5.55	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.92	7.92	7.92	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.51	7.51	7.51	ChEMBL
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	7.94	7.96	8.00	PDSP Ki database
5-HT_5A	5HT5A	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.56	6.56	6.56	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	9.50	9.50	9.50	Guide to Pharmacology
D₁	DRD1	Human	Dopamine	A	pKi	8.54	9.03	9.52	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	9.52	9.52	9.52	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.87	5.87	5.87	ChEMBL
D₅	DRD5	Human	Dopamine	A	pKi	8.40	8.63	8.76	ChEMBL
D₅	DRD5	Human	Dopamine	A	pKi	9.40	9.40	9.40	PDSP Ki database
D₅	DRD5	Human	Dopamine	A	pKi	9.40	9.40	9.40	Guide to Pharmacology
H₁	HRH1	Human	Histamine	A	pKi	6.12	6.12	6.12	ChEMBL

Showing 1 to 19 of 19 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Human	Dopamine	A	pIC50	5.65	5.65	5.65	ChEMBL

Showing 1 to 1 of 1 entry

SKF-83566

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.