tacrine
| SMILES | Nc1c2CCCCc2nc2c1cccc2 |
| InChIKey | YLJREFDVOIBQDA-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 0 |
| Molecular weight (Da) | 198.1 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M2 | ACM2 | Mouse | Acetylcholine (muscarinic) | A | pKi | 6.66 | 6.66 | 6.66 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 5.24 | 5.24 | 5.24 | ChEMBL |
| CB1 | CNR1 | Human | Cannabinoid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| CB2 | CNR2 | Human | Cannabinoid | A | pKi | 6.0 | 6.0 | 6.0 | PDSP Ki database |
| M2 | ACM2 | Mouse | Acetylcholine (muscarinic) | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 5.95 | 5.95 | 5.95 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M2 | ACM2 | Mouse | Acetylcholine (muscarinic) | A | pIC50 | 5.68 | 5.68 | 5.68 | ChEMBL |
| M2 | ACM2 | Pig | Acetylcholine (muscarinic) | A | pEC50 | 5.2 | 5.2 | 5.2 | ChEMBL |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 5.68 | 5.68 | 5.68 | ChEMBL |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.4 | 4.63 | 4.9 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 4.89 | 4.89 | 4.89 | ChEMBL |
| M1 | ACM1 | Mouse | Acetylcholine (muscarinic) | A | pIC50 | 8.24 | 8.24 | 8.24 | Drug Central |
| M1 | ACM1 | Mouse | Acetylcholine (muscarinic) | A | pIC50 | 5.7 | 5.7 | 5.7 | ChEMBL |
| M1 | ACM1 | Mouse | Acetylcholine (muscarinic) | A | pIC50 | 5.7 | 5.7 | 5.7 | Guide to Pharmacology |
| M2 | ACM2 | Mouse | Acetylcholine (muscarinic) | A | pIC50 | 5.68 | 5.68 | 5.68 | Guide to Pharmacology |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 8.25 | 8.25 | 8.25 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 8.25 | 8.25 | 8.25 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 5.56 | 5.56 | 5.56 | ChEMBL |
| M2 | ACM2 | Pig | Acetylcholine (muscarinic) | A | pEC50 | 8.28 | 8.28 | 8.28 | Drug Central |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 4.75 | 4.88 | 5.0 | ChEMBL |