GPCRdb

TFMPP

Agent/drug
Bioactivity

TFMPP

SMILES	FC(F)(F)c1cccc(N2CCNCC2)c1
InChIKey	KKIMDKMETPPURN-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	1
Molecular weight (Da)	230.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT_2C

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.71	6.62	7.09	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.13	6.84	7.49	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.49	6.76	7.12	PDSP Ki database
5-HT_1A	F6Q2H9	Bovine	5-Hydroxytryptamine	A	pKi	6.83	6.83	6.83	PDSP Ki database
5-HT_1A	A0A4X1UTF5	Pig	5-Hydroxytryptamine	A	pKi	6.54	6.54	6.54	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.20	6.55	6.90	Guide to Pharmacology
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.53	7.41	8.65	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	6.36	7.34	8.49	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.61	7.17	7.56	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.10	7.15	7.20	Guide to Pharmacology
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.68	6.97	7.19	PDSP Ki database
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pKi	6.28	6.85	7.23	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	6.17	6.43	6.82	PDSP Ki database
5-HT_1D	5HT1D	Dog	5-Hydroxytryptamine	A	pKi	6.95	6.95	6.95	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.20	5.30	5.40	Guide to Pharmacology
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.20	5.55	6.24	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	Guide to Pharmacology
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
5-HT_1F	5HT1F	Mouse	5-Hydroxytryptamine	A	pKi	6.10	6.10	6.10	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.50	7.50	7.50	Guide to Pharmacology

Showing 1 to 20 of 40 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.54	6.54	6.54	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	7.29	7.43	7.57	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pIC50	6.21	6.21	6.21	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	6.82	6.82	6.82	ChEMBL

Showing 1 to 4 of 4 entries

TFMPP

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT_2C

Compound is not listed as a drug.