GPCRdb

thioridazine

Agent/drug
Bioactivity

thioridazine

SMILES	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2
InChIKey	KLBQZWRITKRQQV-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	370.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.69	8.69	8.69	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	6.40	7.37	7.90	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.59	8.59	8.59	ChEMBL
α_1B	A0A4X1U0M4	Pig	Adrenoceptors	A	pKi	7.80	7.80	7.80	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.62	8.62	8.62	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.06	8.06	8.06	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.54	8.54	8.54	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.30	8.60	8.89	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.06	8.06	8.06	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.30	7.30	7.30	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.34	6.69	6.87	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.76	6.76	6.76	ChEMBL
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	6.59	6.59	6.59	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.47	6.47	6.47	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.60	7.60	7.60	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.26	6.84	7.13	PDSP Ki database

Showing 1 to 20 of 112 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.29	8.29	8.29	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.10	8.10	8.10	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.08	8.08	8.08	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	8.33	8.33	8.33	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	8.23	8.23	8.23	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.88	6.88	6.88	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.42	6.42	6.42	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.77	6.77	6.77	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	5.60	5.60	5.60	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	7.22	7.22	7.22	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.36	8.36	8.36	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	8.10	8.10	8.10	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.89	6.89	6.89	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.36	7.36	7.36	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.15	7.15	7.15	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pIC50	5.89	6.92	7.76	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.71	6.71	6.71	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	8.15	8.15	8.15	Drug Central
D₁	DRD1	Rat	Dopamine	A	pIC50	8.11	8.11	8.11	Drug Central
D₂	DRD2	Rat	Dopamine	A	pIC50	7.22	7.85	8.55	ChEMBL

Showing 1 to 20 of 36 entries

thioridazine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Compound is not listed as a drug.