GPCRdb

ticagrelor

Agent/drug
Bioactivity

ticagrelor

SMILES	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)c2n1
InChIKey	OEKWJQXRCDYSHL-FNOIDJSQSA-N

Chemical Properties

Hydrogen bond acceptors	11
Hydrogen bond donors	4
Rotatable bonds	10
Molecular weight (Da)	522.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb
Ligand site mutations	P2Y₁₂

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

P2Y₁₂	P2Y12	Human	P2Y	A	pKi	8.28	8.27	8.27	Guide to Pharmacology
P2Y₁₂	P2Y12	Human	P2Y	A	pKi	7.85	8.27	8.70	ChEMBL
P2Y₁₂	P2Y12	Human	P2Y	A	pKi	8.11	8.11	8.11	Drug Central

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

FPR3	FPR3	Human	Formylpeptide	A	pIC50	5.43	5.43	5.43	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.31	5.31	5.31	ChEMBL
P2Y₁₂	P2Y12	Human	P2Y	A	pKB	8.59	8.59	8.59	Guide to Pharmacology
P2Y₁₂	P2Y12	Human	P2Y	A	pIC50	5.29	6.81	8.30	ChEMBL
P2Y₁₂	P2Y12	Rat	P2Y	A	pIC50	8.27	8.27	8.27	Drug Central
P2Y₁₂	P2Y12	Rat	P2Y	A	pIC50	5.38	5.38	5.38	ChEMBL
P2Y₁₃	P2Y13	Human	P2Y	A	pIC50	5.85	5.85	5.85	ChEMBL

Showing 1 to 7 of 7 entries

ticagrelor

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 1

Phase II 3

Phase III 9

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem GPCRdb
Ligand site mutations	P2Y₁₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Abdominal aortic aneurysm, unspecified	BD50.4Z	B01A	0.075	2	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Acute ST elevation myocardial infarction	BA41.0	B01A	0.595	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Acute ischaemic heart disease, unspecified	BA4Z	B01A	0.612	4	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	B01A	0.610	4	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Acute non-ST elevation myocardial infarction	BA41.1	B01A	0.260	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Asymptomatic stenosis of intracranial or extracranial artery	BD55	B01A	0.386	2	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	COVID-19	RA01	B01A	0.365	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Cerebral aneurysm, nonruptured	8B22.5	B01A	0.547	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Chronic kidney disease, stage unspecified	GB61.Z	B01A	0.201	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Chronic obstructive pulmonary disease, unspecified	CA22.Z	B01A	0.341	2	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Congenital supravalvar aortic stenosis	LA8A.3	B01A	0.561	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Diseases of arteries or arterioles, unspecified	BD5Z	B01A	0.483	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Diseases of coronary artery, unspecified	BA8Z	B01A	0.613	4	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Other specified atherosclerotic chronic arterial occlusive disease	BD40.Y	B01A	0.562	1	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Pneumonia, organism unspecified	CA40.Z	B01A	0.357	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Sickle cell disease without crisis	3A51.1	B01A	0.353	3	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Stroke not known if ischaemic or haemorrhagic	8B20	B01A	0.598	4	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Thrombophilia, unspecified	3B61.Z	B01A	0.406	4	Yes

Showing 1 to 18 of 18 entries

Join us

Cite us

Main reference

ticagrelor

ticagrelor

Chemical Properties

Database connections

Bioactivities

ticagrelor

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information