GPCRdb

vofopitant

Agent/drug
Bioactivity

vofopitant

SMILES	COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1
InChIKey	XILNRORTJVDYRH-HKUYNNGSSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	432.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

NK₁	NK1R	Human	Tachykinin	A	pKi	10.60	10.60	10.60	Guide to Pharmacology
NK₁	NK1R	Human	Tachykinin	A	pKi	10.30	10.50	10.60	ChEMBL

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

NK₁	NK1R	Human	Tachykinin	A	pIC50	10.10	10.10	10.10	ChEMBL

Showing 1 to 1 of 1 entry

vofopitant

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank GPCRdb

Compound is not listed as a drug.