GPCRdb

AMLODIPINE

Agent/drug
Bioactivity

AMLODIPINE

SMILES	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
InChIKey	HTIQEAQVCYTUBX-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	2
Rotatable bonds	8
Molecular weight (Da)	408.1

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	5.63	5.63	5.63	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.25	8.25	8.25	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.10	5.10	5.10	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.29	8.29	8.29	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.27	5.27	5.27	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.65	6.65	6.65	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.58	6.58	6.58	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.87	5.87	5.87	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central

Showing 1 to 12 of 12 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.22	6.22	6.22	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.75	5.75	5.75	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.54	5.54	5.54	ChEMBL

Showing 1 to 3 of 3 entries

AMLODIPINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.