GPCRdb

LEVODOPA

Agent/drug
Bioactivity

LEVODOPA

SMILES	N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O
InChIKey	WTDRDQBEARUVNC-LURJTMIESA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	3
Molecular weight (Da)	197.1

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 3 of 3 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	7.15	7.15	7.15	ChEMBL

Showing 1 to 1 of 1 entry

LEVODOPA

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 25

Phase II 43

Phase III 35

Phase IV 5

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

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Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Amyotrophic lateral sclerosis	1	8B60.0		0.092
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	2	6A02.Z		0.001
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	3	6C45.2Z		0.288
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Impairment of binocular functions	3	9D46		0.026
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Injury of spinal cord, level unspecified	3	ND51.2		0.011
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Intracranial injury, unspecified	1	NA07.Z		0.004
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Parkinson disease, unspecified	4	8A00.0Z		0.588
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Post traumatic stress disorder	2	6B40		0.003
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Restless legs syndrome	3	7A80		0.037
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Schizophrenia, episode unspecified	2	6A20.Z		0.508
DRD1	D₁ receptor	Dopamine receptors	Aminergic receptors	A	Tourette syndrome	1	8A05.00		0.481
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Age-related macular degeneration, unspecified	2	9B75.0Z		0.007
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Amyotrophic lateral sclerosis	1	8B60.0		0.111
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Asthma	1	CA23		0.037
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Autism spectrum disorder, unspecified	2	6A02.Z		0.499
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	3	6C45.2Z		0.470
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Inherited retinal dystrophies	2	9B70		0.001
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Injury of spinal cord, level unspecified	3	ND51.2		0.024
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Intracranial injury, unspecified	1	NA07.Z		0.077
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	A	Pain, unspecified	2	MG3Z		0.527

Showing 1 to 20 of 67 entries

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LEVODOPA

LEVODOPA

Chemical Properties

Database connections

Bioactivities

LEVODOPA

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information