CHEMBL154508


SMILES O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ccccc2c1
InChIKey DTWIWINSMXUYHB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 455.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Rat Dopamine A pKi 9.24 9.24 9.24 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.98 6.98 6.98 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.43 6.43 6.43 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.47 6.47 6.47 ChEMBL
D3 DRD3 Human Dopamine A pKd 8.52 8.52 8.52 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.1 8.54 8.97 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.28 5.61 5.94 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database