GPCRdb

CLOTRIMAZOLE

Agent/drug
Bioactivity

CLOTRIMAZOLE

SMILES	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
InChIKey	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	344.1

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	4.97	4.97	4.97	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.13	5.13	5.13	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.29	8.29	8.29	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.35	5.35	5.35	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.27	8.27	8.27	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.43	5.43	5.43	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.27	8.27	8.27	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.19	5.19	5.19	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.29	8.29	8.29	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.27	5.27	5.27	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
δ	OPRD	Human	Opioid	A	pKi	5.76	5.76	5.76	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	8.24	8.24	8.24	Drug Central
κ	OPRK	Human	Opioid	A	pKi	5.60	5.60	5.60	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	8.25	8.25	8.25	Drug Central
μ	OPRM	Human	Opioid	A	pKi	6.14	6.14	6.14	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.21	8.21	8.21	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.30	8.30	8.30	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	4.91	4.91	4.91	ChEMBL

Showing 1 to 20 of 64 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	4.58	4.58	4.58	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.34	8.34	8.34	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	4.82	4.82	4.82	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	4.92	4.92	4.92	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.09	5.09	5.09	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	4.95	4.95	4.95	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	5.33	5.33	5.33	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	5.14	5.14	5.14	ChEMBL
δ	OPRD	Human	Opioid	A	pIC50	5.30	5.30	5.30	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	5.20	5.20	5.20	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	5.74	5.74	5.74	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	4.75	4.75	4.75	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	8.32	8.32	8.32	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	4.56	4.56	4.56	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	4.95	4.95	4.95	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	4.93	4.93	4.93	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	4.84	4.84	4.84	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	4.90	4.90	4.90	ChEMBL
A₁	AA1R	Human	Adenosine	A	pIC50	4.87	4.87	4.87	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pIC50	4.90	4.90	4.90	ChEMBL

Showing 1 to 20 of 44 entries

CLOTRIMAZOLE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.