GPCRdb

CHEMBL1766103

Agent/drug
Bioactivity

CHEMBL1766103

SMILES	Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1
InChIKey	GXGVWEMSSIKHOZ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	6
Molecular weight (Da)	432.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.78	5.78	5.78	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.07	6.07	6.07	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.07	6.07	6.07	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.55	5.55	5.55	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	5.25	5.25	5.25	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.54	6.54	6.54	ChEMBL
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.24	5.24	5.24	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.46	5.46	5.46	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	6.07	6.07	6.07	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.66	5.66	5.66	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	6.38	6.38	6.38	ChEMBL
D₅	DRD5	Human	Dopamine	A	pKi	6.00	6.00	6.00	ChEMBL
SST2	SSR2	Human	Somatostatin	A	pKi	10.60	10.60	10.60	ChEMBL

Showing 1 to 13 of 13 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

apelin	APJ	Human	Apelin	A	pIC50	5.47	5.47	5.47	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	5.44	5.44	5.44	ChEMBL
FPR1	FPR1	Human	Formylpeptide	A	pIC50	5.29	5.29	5.29	ChEMBL
GPR119	GP119	Human	GPR18, GPR55 and GPR119	A	pIC50	5.38	5.38	5.38	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.58	5.58	5.58	ChEMBL
GPR35	GPR35	Human	A orphans	A	pIC50	5.41	5.41	5.41	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.54	5.54	5.54	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.34	5.34	5.34	ChEMBL
S1P₁	S1PR1	Human	Lysophospholipid (S1P)	A	pIC50	5.49	5.49	5.49	ChEMBL
SST2	SSR2	Human	Somatostatin	A	pIC50	8.32	8.32	8.32	ChEMBL

Showing 1 to 10 of 10 entries

CHEMBL1766103

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.