GPCRdb

CHEMBL1774383

Agent/drug
Bioactivity

CHEMBL1774383

SMILES	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1
InChIKey	DXTFDOIEUMNMMV-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	9
Molecular weight (Da)	462.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.31	7.31	7.31	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.69	5.69	5.69	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	6.41	6.41	6.41	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	7.69	7.69	7.69	ChEMBL

Showing 1 to 4 of 4 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	7.14	7.14	7.14	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.16	6.29	6.41	ChEMBL

Showing 1 to 2 of 2 entries

CHEMBL1774383

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.