GPCRdb

CHEMBL1774535

Agent/drug
Bioactivity

CHEMBL1774535

SMILES	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1
InChIKey	VIHBCLOGDPFGGP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	462.1

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.65	6.65	6.65	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.67	6.67	6.67	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	6.28	6.28	6.28	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.40	8.40	8.40	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	5.47	5.47	5.47	ChEMBL

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	5.67	5.67	5.67	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.91	6.10	6.28	ChEMBL

Showing 1 to 2 of 2 entries

CHEMBL1774535

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.