CHEMBL1644978


SMILES OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
InChIKey QBWLTDPVSJCLIE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 537.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.05 6.05 6.05 ChEMBL
D5 DRD5 Human Dopamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.07 6.07 6.07 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.01 6.01 6.01 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.42 6.42 6.42 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.1 6.1 6.1 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.37 6.37 6.37 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.77 5.77 5.77 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.68 6.68 6.68 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.86 5.86 5.86 ChEMBL
κ OPRK Human Opioid A pKi 5.57 5.57 5.57 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.71 6.71 6.71 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.78 5.78 5.78 ChEMBL
H2 HRH2 Human Histamine A pKi 6.26 6.26 6.26 ChEMBL
δ OPRD Human Opioid A pKi 5.85 5.85 5.85 ChEMBL
μ OPRM Human Opioid A pKi 6.45 6.45 6.45 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database