GPCRdb

GW-328267

Agent/drug
Bioactivity

GW-328267

SMILES	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1
InChIKey	FLBKPDIBGNWXMT-NIQZGXKPSA-N

Chemical Properties

Hydrogen bond acceptors	14
Hydrogen bond donors	5
Rotatable bonds	8
Molecular weight (Da)	482.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A₁	AA1R	Human	Adenosine	A	pKi	6.00	6.29	6.43	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pKi	7.34	7.78	8.64	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pKi	5.89	5.89	5.89	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKi	7.04	7.29	7.80	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKd	8.30	8.30	8.30	ChEMBL

Showing 1 to 5 of 5 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

A₁	AA1R	Human	Adenosine	A	pEC50	6.05	6.05	6.05	ChEMBL
A_2A	AA2AR	Rat	Adenosine	A	pEC50	8.00	8.00	8.00	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pEC50	8.05	8.37	9.00	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pIC50	9.40	9.40	9.40	ChEMBL
A_2B	AA2BR	Human	Adenosine	A	pEC50	5.89	6.30	7.29	ChEMBL
A₃	AA3R	Human	Adenosine	A	pEC50	8.38	8.38	8.38	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	8.30	8.30	8.30	ChEMBL

Showing 1 to 7 of 7 entries

GW-328267

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.