GPCRdb

SILDENAFIL

Agent/drug
Bioactivity

SILDENAFIL

SMILES	CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12
InChIKey	BNRNXUUZRGQAQC-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	8
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	474.2

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.09	6.09	6.09	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
A₁	AA1R	Human	Adenosine	A	pKi	6.06	6.06	6.06	ChEMBL
A₁	AA1R	Human	Adenosine	A	pKi	8.22	8.22	8.22	Drug Central
A_2A	AA2AR	Human	Adenosine	A	pKi	6.70	6.78	6.85	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pKi	8.17	8.17	8.17	Drug Central

Showing 1 to 6 of 6 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.84	5.84	5.84	ChEMBL
A₁	AA1R	Human	Adenosine	A	pIC50	5.83	5.83	5.83	ChEMBL
A_2A	AA2AR	Human	Adenosine	A	pIC50	6.60	6.60	6.60	ChEMBL

Showing 1 to 3 of 3 entries

SILDENAFIL

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.