4-DAMP


SMILES O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C
InChIKey HYJRTXSYDAFGJK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 324.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations M1 M3

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 9.3 9.3 9.3 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.4 8.4 8.4 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.9 8.9 8.9 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 9.0 9.0 9.0 Guide to Pharmacology
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 9.1 9.1 9.1 Guide to Pharmacology
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.2 8.2 8.2 Guide to Pharmacology
M5 ACM5 Rat Acetylcholine (muscarinic) A pKi 8.9 8.9 8.9 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.9 8.9 8.9 Guide to Pharmacology
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 9.2 9.2 9.2 Guide to Pharmacology
M1 ACM1 Fruit fly Acetylcholine (muscarinic) A pKi 7.75 7.79 7.82 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.51 8.94 9.37 PDSP Ki database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 8.25 8.43 8.85 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 7.89 8.13 8.43 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.44 8.77 9.23 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.33 8.38 8.42 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 9.17 9.25 9.3 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.69 8.9 9.24 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.98 8.98 8.98 PDSP Ki database
M4 ACM4 Chicken Acetylcholine (muscarinic) A pKi 8.32 8.32 8.32 PDSP Ki database
M4 ACM4 Mouse Acetylcholine (muscarinic) A pKi 8.25 8.25 8.25 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.57 8.98 9.24 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.96 8.96 8.96 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.64 7.64 7.64 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 8.57 8.57 8.57 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.6 9.27 9.66 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 9.3 9.3 9.3 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 9.06 9.24 9.43 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 9.32 9.45 9.66 ChEMBL
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 9.29 9.29 9.29 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.4 8.4 8.4 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 9.23 9.23 9.23 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.94 8.94 8.94 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 8.35 8.35 8.35 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 7.26 7.26 7.26 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 8.29 9.08 9.51 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 8.72 9.1 9.31 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 9.08 9.3 9.49 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 7.8 7.88 7.95 ChEMBL