5-OH-DPAT


SMILES CCCN(C1CCc2c(C1)cccc2O)CCC
InChIKey MDBWEQVKJDMEMK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 247.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Mouse 5-Hydroxytryptamine A pKi 8.4 8.4 8.4 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.33 6.33 6.33 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.46 6.46 6.46 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.23 7.56 8.22 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.36 8.82 9.18 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.98 5.98 5.98 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.82 7.68 9.15 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pEC50 7.38 7.68 7.98 ChEMBL
D3 DRD3 Human Dopamine A pEC50 8.91 9.38 9.85 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 8.4 8.4 8.4 ChEMBL