GPCRdb

PSILOCYBINE

Agent/drug
Bioactivity

PSILOCYBINE

SMILES	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12
InChIKey	QVDSEJDULKLHCG-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	3
Rotatable bonds	5
Molecular weight (Da)	284.1

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
δ	OPRD	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.67	5.67	5.67	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.71	6.71	6.71	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.01	7.01	7.01	ChEMBL
5-HT_2B	F6QI78	Bovine	5-Hydroxytryptamine	A	pKi	6.22	6.22	6.22	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.01	7.01	7.01	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.38	6.38	6.38	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	6.22	6.22	6.22	PDSP Ki database
CB₁	CNR1	Human	Cannabinoid	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 20 of 33 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	5.46	5.46	5.46	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pEC50	7.13	7.13	7.13	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pEC50	6.30	6.30	6.30	ChEMBL

Showing 1 to 3 of 3 entries

PSILOCYBINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 6

Phase II 12

Phase III 1

Phase IV 0

Database connections

ChEMBL_compound_ids PubChem PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

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Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Alcohol dependence, unspecified	2	6C40.2Z		0.268
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Anorexia Nervosa, unspecified	2	6B80.Z		0.508
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Anxiety	1	MB24.3		0.575
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Bipolar type I disorder, unspecified	2	6A60.Z		0.609
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Chronic widespread pain	1	MG30.01		0.561
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Cocaine dependence, unspecified	2	6C45.2Z		0.460
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Depressive disorders, unspecified	3	6A7Z		0.607
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Disorders due to use of opioids, unspecified	2	6C43.Z		0.108
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Headache, not elsewhere classified	1	MB4D		0.468
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Low back pain, unspecified	2	ME84.2Z		0.379
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Lyme borreliosis, unspecified	1	1C1G.Z		0.037
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Migraine, unspecified	1	8A80.Z		0.479
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Nicotine dependence, unspecified	2	6C4A.2Z		0.089
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Obsessive-compulsive disorder, unspecified	1	6B20.Z		0.561
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Other specified depressive disorders	2	6A7Y		0.552
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Post traumatic stress disorder	2	6B40		0.585
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	2	6A70.3		0.632
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	A	Stimulant dependence including amphetamines, methamphetamine or methcathinone, unspecified	2	6C46.2Z		0.546

Showing 1 to 18 of 18 entries

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Main reference

PSILOCYBINE

PSILOCYBINE

Chemical Properties

Database connections

Bioactivities

PSILOCYBINE

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information