GPCRdb

BP 897

Agent/drug
Bioactivity

BP 897

SMILES	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3c2)CC1
InChIKey	MNHDKMDLOJSCGN-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	8
Molecular weight (Da)	417.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.22	7.22	7.22	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.98	8.01	8.04	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.57	6.57	6.57	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.60	7.58	8.56	ChEMBL
α_2A	ADA2A	Rat	Adrenoceptors	A	pKi	7.08	7.08	7.08	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.88	6.88	6.88	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.08	7.08	7.08	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	6.60	6.60	6.60	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.08	7.08	7.08	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.76	7.06	7.25	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.78	6.78	6.78	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.48	7.48	7.48	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.23	6.45	6.66	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	6.12	6.12	6.12	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	7.53	7.53	7.53	ChEMBL
D₁	DRD1	Pig	Dopamine	A	pKi	6.12	6.12	6.12	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pKi	5.52	5.52	5.52	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.95	6.14	6.38	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	6.33	6.77	7.21	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	6.61	6.90	7.47	ChEMBL

Showing 1 to 20 of 30 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₂	DRD2	Rat	Dopamine	A	pIC50	7.55	7.58	7.62	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	9.14	9.27	9.39	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	8.52	8.64	8.74	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.25	8.10	8.74	ChEMBL
D₃	DRD3	Green monkey	Dopamine	A	pEC50	8.52	8.52	8.52	ChEMBL
D₄	DRD4	Human	Dopamine	A	pEC50	7.31	7.31	7.31	ChEMBL
FFA4	FFAR4	Human	Free fatty acid	A	pEC50	5.83	5.83	5.83	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.70	4.78	4.85	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.80	4.80	4.80	ChEMBL

Showing 1 to 9 of 9 entries

BP 897

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.