GPCRdb

afamelanotide

SMILES	None
InChIKey	UAHFGYDRQSXQEB-LEBBXHLNSA-N
Sequence	SYSXEHFRWGKPV

Chemical properties

Hydrogen bond acceptors	None
Hydrogen bond donors	None
Rotatable bonds	None
Molecular weight (Da)

Drug properties

Molecular type	Peptide
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem PubChem PubChem PubChem GPCRdb
Structure pdb	7F54 7PIV
Ligand site mutations	MC₄

Sankey plot

Bioactivities

Affinity
Potency

Receptor					Activity				Source
GTP	Uniprot	Species	Family	Class	Type	Min	Avg	Max	Database
MC₃	MC3R	Human	Melanocortin	A	pKi	8.9	8.9	8.9	Guide to Pharmacology
MC₄	MC4R	Human	Melanocortin	A	pKi	8.5	8.65	8.8	Guide to Pharmacology
MC₄	MC4R	Human	Melanocortin	A	pKi	7.72	9.0	9.52	ChEMBL
MC₁	MSHR	Human	Melanocortin	A	pKi	8.74	9.46	10.34	ChEMBL
MC₃	MC3R	Human	Melanocortin	A	pKi	9.11	9.14	9.17	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pKi	8.0	8.66	9.32	ChEMBL

Receptor					Activity				Source
GTP	Uniprot	Species	Family	Class	Type	Min	Avg	Max	Database
MC₁	MSHR	Human	Melanocortin	A	pIC50	10.0	10.0	10.0	Guide to Pharmacology
MC₅	MC5R	Human	Melanocortin	A	pIC50	9.0	9.0	9.0	Guide to Pharmacology
MC₄	MC4R	Human	Melanocortin	A	pIC50	7.85	8.96	9.82	ChEMBL
MC₄	MC4R	Human	Melanocortin	A	pEC50	8.05	9.27	10.77	ChEMBL
MC₁	MSHR	Human	Melanocortin	A	pEC50	9.3	9.95	10.64	ChEMBL
MC₁	MSHR	Human	Melanocortin	A	pIC50	9.29	9.29	9.29	ChEMBL
MC₃	MC3R	Rat	Melanocortin	A	pEC50	10.0	10.0	10.0	ChEMBL
MC₃	MC3R	Human	Melanocortin	A	pEC50	8.17	9.15	9.89	ChEMBL
MC₃	MC3R	Human	Melanocortin	A	pIC50	8.42	8.63	8.93	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pIC50	8.66	8.9	9.07	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pEC50	8.96	9.21	9.64	ChEMBL
MC₃	MC3R	Mouse	Melanocortin	A	pEC50	7.12	9.76	10.2	ChEMBL
MC₃	MC3R	Mouse	Melanocortin	A	pIC50	8.09	8.25	8.38	ChEMBL
MC₁	MSHR	Mouse	Melanocortin	A	pEC50	7.92	10.38	11.0	ChEMBL
MC₁	MSHR	Mouse	Melanocortin	A	pIC50	9.51	9.52	9.54	ChEMBL
MC₄	MC4R	Mouse	Melanocortin	A	pEC50	6.92	9.42	10.01	ChEMBL
MC₄	MC4R	Mouse	Melanocortin	A	pIC50	8.38	8.73	8.96	ChEMBL
MC₅	MC5R	Mouse	Melanocortin	A	pEC50	6.77	9.71	10.52	ChEMBL
MC₅	MC5R	Mouse	Melanocortin	A	pIC50	6.85	6.85	6.85	ChEMBL