AFDX384


SMILES CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC
InChIKey MZDYABXXPZNUCT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Molecular weight (Da) 478.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.5 7.5 7.5 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.1 8.15 8.2 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 9.0 9.0 9.0 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.2 7.2 7.2 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.3 7.65 8.0 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKd 8.7 8.7 8.7 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.3 6.3 6.3 Guide to Pharmacology
M1 ACM1 Fruit fly Acetylcholine (muscarinic) A pKi 8.21 8.27 8.32 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.18 7.18 7.18 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.51 7.64 7.91 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.22 8.24 8.28 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.0 8.0 8.0 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.27 6.27 6.27 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database