α-methyl-5-HT


SMILES CC(Cc1c[nH]c2c1cc(O)cc2)N
InChIKey LYPCGXKCQDYTFV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 2
Molecular weight (Da) 190.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT2A 5-HT6

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.1 6.35 6.6 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.9 6.95 7.0 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.9 8.1 8.3 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.9 7.75 8.6 Guide to Pharmacology
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 5.5 5.5 5.5 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 Guide to Pharmacology
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 5.6 6.1 6.6 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.82 6.82 6.82 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.0 6.54 7.07 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.82 6.82 6.82 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.05 7.17 7.38 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.89 7.89 7.89 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.22 7.85 8.18 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.92 7.92 7.92 ChEMBL
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 6.9 7.43 9.0 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 5.84 6.09 6.58 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.92 8.18 8.7 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.98 7.98 7.98 PDSP Ki database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 5.7 5.7 5.7 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.92 6.92 6.92 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.74 6.74 6.74 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.39 7.7 7.92 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.94 8.26 8.57 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.92 7.92 7.92 ChEMBL
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.7 6.7 6.7 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 8.0 8.0 8.0 Guide to Pharmacology
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 7.23 7.23 7.23 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pEC50 8.38 8.38 8.38 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pEC50 8.74 8.74 8.74 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 8.7 8.7 8.7 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 6.42 6.42 6.42 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 7.71 7.71 7.71 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 6.2 6.2 6.2 ChEMBL