AM281


SMILES Ic1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCOCC1
InChIKey AJFFBPZYXRNAIC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 556.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB1 CNR1 Rat Cannabinoid A pKi 7.9 7.9 7.9 Guide to Pharmacology
CB1 CNR1 Rat Cannabinoid A pKi 7.91 8.13 8.35 ChEMBL
CB1 CNR1 Human Cannabinoid A pKi 6.38 7.38 7.88 ChEMBL
CB1 CNR1 Human Cannabinoid A pKi 6.37 6.37 6.37 PDSP Ki database
CB2 CNR2 Human Cannabinoid A pKi 5.38 5.38 5.38 ChEMBL
CB2 CNR2 Rat Cannabinoid A pKi 5.38 5.38 5.38 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR55 GPR55 Human GPR18, GPR55 and GPR119 A pIC50 7.87 8.2 8.52 Guide to Pharmacology
GPR55 GPR55 Human GPR18, GPR55 and GPR119 A pEC50 4.87 4.87 4.87 ChEMBL