AZD3778


SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl
InChIKey QVLZVRFIGXNZMN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 525.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 7.5 7.5 7.5 Guide to Pharmacology
CCR3 CCR3 Human Chemokine A pKi 8.2 8.2 8.2 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 7.5 7.5 7.5 ChEMBL
CCR3 CCR3 Human Chemokine A pKi 8.2 8.2 8.2 ChEMBL
CCR3 CCR3 Human Chemokine A pKd 7.0 7.0 7.0 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pIC50 7.4 7.4 7.4 ChEMBL
CCR3 CCR3 Human Chemokine A pIC50 8.09 8.09 8.09 ChEMBL