balovaptan


SMILES CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1
InChIKey GMPZPHGHNDMRKL-RZDIXWSQSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 409.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKd 11.57 11.57 11.57 Guide to Pharmacology
V1A V1AR Human Vasopressin and oxytocin A pKd 8.59 8.59 8.59 Guide to Pharmacology
V2 V2R Human Vasopressin and oxytocin A pKd 5.0 5.0 5.0 Guide to Pharmacology
OT OXYR Human Vasopressin and oxytocin A pKi 5.15 5.15 5.15 Guide to Pharmacology
V1A V1AR Human Vasopressin and oxytocin A pKi 9.15 9.15 9.15 ChEMBL
V2 V2R Human Vasopressin and oxytocin A pKi 5.92 5.92 5.92 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V1A V1AR Human Vasopressin and oxytocin A pIC50 8.52 8.52 8.52 ChEMBL