bremelanotide


SMILES CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)O)NC(=O)C
InChIKey FFHBJDQSGDNCIV-MFVUMRCOSA-N
Sequence XDHXRWK

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7F55 7F4I

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC3 MC3R Human Melanocortin A pKi 7.28 7.28 7.28 Guide to Pharmacology
MC4 MC4R Human Melanocortin A pKi 9.6 9.6 9.6 Guide to Pharmacology
MC5 MC5R Human Melanocortin A pKi 7.77 7.77 7.77 Guide to Pharmacology
MC1 MSHR Human Melanocortin A pKi 8.19 8.59 8.72 ChEMBL
MC5 MC5R Human Melanocortin A pKi 7.77 7.77 7.77 ChEMBL
MC3 MC3R Human Melanocortin A pKi 6.7 6.85 7.28 ChEMBL
MC4 MC4R Human Melanocortin A pKi 7.61 8.14 9.6 ChEMBL
MC4 MC4R Human Melanocortin A pKd 8.1 8.1 8.1 Drug Central
MC5 MC5R Human Melanocortin A pKi 8.11 8.11 8.11 Drug Central
MC1 MSHR Human Melanocortin A pKi 8.19 8.19 8.19 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC1 MSHR Human Melanocortin A pEC50 10.02 10.08 10.11 ChEMBL
MC5 MC5R Human Melanocortin A pIC50 6.7 6.7 6.71 ChEMBL
MC3 MC3R Human Melanocortin A pEC50 8.62 8.99 9.17 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 8.39 9.22 9.92 ChEMBL
MC3 MC3R Human Melanocortin A pEC50 8.06 8.06 8.06 Drug Central
MC1 MSHR Human Melanocortin A pEC50 8.0 8.0 8.0 Drug Central