butaprost (free acid form)


SMILES CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O
InChIKey PAYNQYXOKJDXAV-ZHIWTBQHSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 13
Molecular weight (Da) 394.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP1 PD2R Human Prostanoid A pKi 4.9 4.9 4.9 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKi 5.9 6.45 7.0 Guide to Pharmacology
EP4 PE2R4 Human Prostanoid A pKi 4.7 4.7 4.7 Guide to Pharmacology
IP PI2R Human Prostanoid A pKi 4.3 4.3 4.3 Guide to Pharmacology
TP TA2R Human Prostanoid A pKi 4.7 4.7 4.7 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pKi 4.93 4.93 4.93 Guide to Pharmacology
EP2 PE2R2 Rat Prostanoid A pKi 7.2 7.2 7.2 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKi 4.8 4.8 4.8 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKi 7.14 7.14 7.14 ChEMBL
EP3 PE2R3 Human Prostanoid A pKi 5.78 5.78 5.78 Guide to Pharmacology
IP PI2R Human Prostanoid A pKi 6.06 6.06 6.06 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP2 PE2R2 Human Prostanoid A pEC50 7.5 7.5 7.5 ChEMBL
IP PI2R Human Prostanoid A pIC50 7.6 7.6 7.6 ChEMBL