carbachol
| SMILES | NC(=O)OCC[N+](C)(C)C |
| InChIKey | VPJXQGSRWJZDOB-UHFFFAOYSA-O |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 3 |
| Molecular weight (Da) | 147.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Sankey plot
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Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 3.2 | 4.25 | 5.3 | Guide to Pharmacology |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 4.2 | 4.95 | 5.7 | Guide to Pharmacology |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 4.0 | 4.2 | 4.4 | Guide to Pharmacology |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 4.3 | 4.6 | 4.9 | Guide to Pharmacology |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 4.9 | 4.9 | 4.9 | Guide to Pharmacology |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pKi | 5.7 | 5.7 | 5.7 | Guide to Pharmacology |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 3.9 | 3.9 | 3.9 | Guide to Pharmacology |
| M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pKi | 4.2 | 4.2 | 4.2 | Guide to Pharmacology |
| M2 | ACM2 | Mouse | Acetylcholine (muscarinic) | A | pKi | 4.18 | 6.14 | 8.1 | ChEMBL |
| M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pKi | 4.86 | 5.4 | 6.16 | ChEMBL |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pKi | 5.3 | 6.76 | 8.4 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 5.24 | 6.35 | 7.51 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 4.16 | 4.55 | 5.37 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 5.12 | 5.7 | 7.62 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 4.29 | 4.58 | 5.2 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 5.39 | 6.43 | 7.7 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 4.2 | 4.88 | 6.77 | ChEMBL |
| M4 | ACM4 | Rat | Acetylcholine (muscarinic) | A | pKi | 5.58 | 5.58 | 5.58 | ChEMBL |
| M1 | ACM1 | Mouse | Acetylcholine (muscarinic) | A | pKi | 6.13 | 7.09 | 7.7 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pEC50 | 4.92 | 6.99 | 8.37 | ChEMBL |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 4.72 | 6.15 | 7.47 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 4.35 | 5.69 | 7.64 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pEC50 | 6.19 | 6.19 | 6.19 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pEC50 | 5.05 | 5.65 | 6.44 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 4.6 | 4.6 | 4.6 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pEC50 | 4.22 | 5.99 | 7.35 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.14 | 6.96 | 9.4 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.04 | 5.55 | 6.06 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pEC50 | 4.82 | 6.37 | 7.68 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pEC50 | 4.21 | 6.23 | 7.13 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.46 | 6.75 | 8.42 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pEC50 | 4.47 | 5.34 | 6.6 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 5.0 | 5.58 | 6.34 | ChEMBL |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 5.1 | 5.1 | 5.1 | ChEMBL |
| M4 | ACM4 | Rat | Acetylcholine (muscarinic) | A | pIC50 | 6.64 | 6.64 | 6.64 | ChEMBL |
| M1 | ACM1 | Mouse | Acetylcholine (muscarinic) | A | pEC50 | 4.4 | 4.4 | 4.4 | ChEMBL |
| M3 | ACM3 | Mouse | Acetylcholine (muscarinic) | A | pEC50 | 5.0 | 5.0 | 5.0 | ChEMBL |