cinnarizine


SMILES c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1
InChIKey DERZBLKQOCDDDZ-JLHYYAGUSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 368.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Sankey plot

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pKi 7.88 7.88 7.88 Guide to Pharmacology
α1B ADA1B Rat Adrenoceptors A pKi 6.3 6.3 6.3 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 6.11 6.11 6.11 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.24 6.24 6.24 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 5.99 5.99 5.99 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.26 6.26 6.26 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.02 7.02 7.02 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.29 6.29 6.29 ChEMBL
H1 HRH1 Human Histamine A pKi 8.06 8.06 8.06 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.79 6.79 6.79 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.21 6.21 6.21 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.78 6.78 6.78 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.33 6.33 6.33 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.22 6.22 6.22 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.07 7.07 7.07 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.99 6.99 6.99 ChEMBL
μ OPRM Human Opioid A pKi 6.04 6.04 6.04 ChEMBL
H4 HRH4 Human Histamine A pKi 6.85 6.85 6.85 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.59 6.59 6.59 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.2 8.2 8.2 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.2 8.2 8.2 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.17 8.17 8.17 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.22 8.22 8.22 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
D2 DRD2 Human Dopamine A pKi 8.18 8.18 8.18 Drug Central
D3 DRD3 Human Dopamine A pKi 8.15 8.15 8.15 Drug Central
H4 HRH4 Human Histamine A pKi 8.16 8.16 8.16 Drug Central
μ OPRM Human Opioid A pKi 8.22 8.22 8.22 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.2 8.2 8.2 Drug Central
H1 HRH1 Human Histamine A pKi 8.09 8.09 8.09 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1B ADA1B Rat Adrenoceptors A pIC50 6.04 6.04 6.04 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 5.72 5.72 5.72 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 5.93 5.93 5.93 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 5.65 5.65 5.65 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pIC50 6.12 6.12 6.12 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 6.19 6.19 6.19 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pIC50 5.44 5.44 5.44 ChEMBL
H1 HRH1 Human Histamine A pIC50 7.13 7.13 7.13 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pIC50 6.12 6.12 6.12 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 5.96 5.96 5.96 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.35 6.35 6.35 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 6.14 6.14 6.14 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 5.6 5.6 5.6 ChEMBL
D3 DRD3 Human Dopamine A pIC50 6.6 6.6 6.6 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.44 6.44 6.44 ChEMBL
μ OPRM Human Opioid A pIC50 5.64 5.64 5.64 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.11 6.11 6.11 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 8.22 8.22 8.22 Drug Central
α1A ADA1A Rat Adrenoceptors A pIC50 8.24 8.24 8.24 Drug Central
NPS NPSR1 Human Neuropeptide S A Potency 4.5 4.63 4.9 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.3 5.53 5.75 ChEMBL